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Signs of dementia 'can start at age of three'

A study suggests a gene mutation that increases the risk of developing dementia affects children as young as three.

A study suggests a gene mutation that increases the risk of developing dementia affects children as young as three. Photo: Andrzej Wojcicki


London: The Alzheimer’s gene, which seriously raises the risk of developing dementia, is already affecting carriers by the age of three, shrinking their brains and lowering cognition, a study suggests.

Children who carry the APOEe4 gene mutation, which raises the chance of dementia 15-fold, were found to do less well in memory, attention and function tests. Areas of the brain affected by Alzheimer’s disease, such as the hippocampus and parietal gyri, were also found to be up to 22 per cent smaller in volume.

Around 14 per cent of people carry the APOEe4 mutation. The research is the first to show that genetic changes which can lead to Alzheimer’s are affecting the brain very early in life.

Scientists from the University of Hawaii, Yale and Harvard say screening for the gene could help doctors identify which children could benefit from early interventions, such as educational help, preventative treatments, health monitoring and increased exercise.

The study involved 1187 people aged between three and 20 who took part in genetic tests and brain scans as well as undertaking a series of tests to measure their thinking and memory skills. The subjects had no other disorders which might affect brain development.

Lead author Dr Linda Chang said: “The APOEe4 carriers show the strongest effects, with negative influences on brain structures and cognition mirroring those in elderly participants and patients with Alzheimer’s disease.”

The most common kind of dementia is Alzheimer’s disease. But scientists are still struggling to determine what causes the condition, and despite 412 drug trials, nothing has been shown to combat the disease so far. The researchers think the APOEe4 gene slows brain development and could be a target for future medication. APOEe4 is also known to make people susceptible to disease so some scientists believe Alzheimer’s could be triggered by an infection and may be fought with antibiotics.

Ian Le Guillou, research officer at Alzheimer’s Society, said: “These interesting findings suggest that people with the APOEe4 gene – which increases the risk of developing Alzheimer’s disease – have differences in their brains from childhood.

“However, we need to be cautious in interpreting these results as, although this study involved over 1000 children, there were less than 30 in the highest-risk group. We would need to see these results replicated in a larger group, as well as having longer term follow-ups to better understand how the changes in the brain progress with age.”

He added: “Although people with the gene are at an increased risk of dementia, there are still things they can do to lower their chances of developing the condition. This includes taking regular exercise, not smoking and keeping their blood pressure in check.”

The research was published in the journal Neurology.




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